Iwai J, Knudsen K D, Dahl L K, Heine M, Leitl G
J Exp Med. 1969 Mar 1;129(3):507-22. doi: 10.1084/jem.129.3.507.
The effects of several renal manipulations including uninephrectomy, unilateral renal artery constriction, and a combination of these two (Goldblatt procedure) were studied in two strains of rats with opposite constitutional predispositions to experimental hypertension. The protective value of intact renal tissue to protect against hypertension was shown to be genetically determined. The Goldblatt procedure carried out on only one member of a parabiotic pair induced hypertension in this operated rat but significant hypertension developed in the intact partner only when the operated animal belonged to the strain predisposed to hypertension. It was speculated that there were qualitative differences in the pressor signals of the two strains of rats. In the strain genetically predisposed to hypertension there are at least two pressor principles: (a) one which is common to both strains, not transmittable via the parabiosis junction and presumably related to the renin-angiotensin system; and (b) a second which is specific for the hypertension-prone strain and can be transmitted through the parabiosis junction. This transmittable agent is probably identical with the factor that produces salt hypertension and is associated with the salt-excreting mechanism.
在两种对实验性高血压具有相反体质易感性的大鼠品系中，研究了包括单侧肾切除、单侧肾动脉狭窄以及这两种操作的组合（戈德布拉特手术）在内的几种肾脏操作的影响。完整肾组织对预防高血压的保护作用显示是由基因决定的。对联体动物对中的仅一只进行戈德布拉特手术，在这只手术大鼠中诱发了高血压，但仅当手术动物属于易患高血压的品系时，完整的伙伴才会出现明显的高血压。据推测，两种大鼠品系的升压信号存在质的差异。在遗传上易患高血压的品系中，至少有两种升压原理：(a) 一种是两种品系共有的，不能通过联体连接传递，可能与肾素-血管紧张素系统有关；(b) 另一种是易患高血压品系特有的，可以通过联体连接传递。这种可传递的因子可能与产生盐性高血压并与排盐机制相关的因子相同。
