• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抑制剂（或激活剂）参与生物系统的分子顺序。

Molecular order of participation of inhibitors (or activators) in biological systems.

作者信息

Loftfield R B, Eigner E A

出版信息

Science. 1969 Apr 18;164(3877):305-8. doi: 10.1126/science.164.3877.305.

DOI:10.1126/science.164.3877.305
PMID:4304859
Abstract

From a Hill plot it is frequently possible to determine whether exactly one, two, or several inhibitor (or activator) molecules are involved in a critical rate-determining biological process.

摘要

从希尔图中，通常可以确定在一个关键的限速生物学过程中，究竟是一个、两个还是几个抑制剂（或激活剂）分子参与其中。

相似文献

1
Molecular order of participation of inhibitors (or activators) in biological systems.抑制剂（或激活剂）参与生物系统的分子顺序。
Science. 1969 Apr 18;164(3877):305-8. doi: 10.1126/science.164.3877.305.
2
Inhibition studies on liver alcohol dehydrogenase.
Eur J Biochem. 1968 May;4(4):548-54. doi: 10.1111/j.1432-1033.1968.tb00247.x.
3
[ACTIVE SITES OF ATP: ARGININE PHOSPHOTRANSFERASE].[ATP的活性位点：精氨酸磷酸转移酶]
Biochim Biophys Acta. 1964 Aug 26;89:255-65.
4
Degradation of 5'-deoxyadenosylcobalamin by ribonucleoside triphosphate reductase and binding of degradation products to the active center.
Biochemistry. 1971 Oct 12;10(21):3959-68. doi: 10.1021/bi00797a025.
5
The reaction mechanism of aldose reductase from Rhodotorula.红酵母中醛糖还原酶的反应机制。
Biochim Biophys Acta. 1971 Sep 22;242(3):523-31. doi: 10.1016/0005-2744(71)90145-8.
6
[ON THE DETERMINATION OF ACTIVE SITES OF CERTAIN ENZYMES. VI. A STUDY OF INHIBITION IN A REVERSIBLE REACTION].
Biochim Biophys Acta. 1964 Jul 8;89:1-22.
7
Glucose dehydrogenase activity of yeast glucose 6-phosphate dehydrogenase. Inhibition by adenosine 5'-triphosphate and other nucleoside 5'-triphosphates and diphosphates.
Biochemistry. 1970 Feb 3;9(3):610-6. doi: 10.1021/bi00805a023.
8
Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies.烟酰胺腺嘌呤二核苷酸自旋标记类似物与乙醇脱氢酶的相互作用。I. 合成、动力学及电子顺磁共振研究。
Biochemistry. 1969 Feb;8(2):526-33. doi: 10.1021/bi00830a011.
9
Magnetic resonance studies of the geometry of bound nicotinamide adenine dinucleotide and isobutyramide on spin-labeled alcohol dehydrogenase.自旋标记乙醇脱氢酶上结合的烟酰胺腺嘌呤二核苷酸和异丁酰胺几何结构的磁共振研究。
Biochemistry. 1974 Apr 9;13(8):1711-8. doi: 10.1021/bi00705a024.
10
The role of essential-SH groups of yeast alcohol dehydrogenase.
Biochim Biophys Acta. 1969;185(2):461-3. doi: 10.1016/0005-2744(69)90439-2.

引用本文的文献

1
Modification of the erythrocyte membrane by sulfhydryl group reagents.巯基试剂对红细胞膜的修饰。
J Membr Biol. 1972 Dec;7(1):285-312. doi: 10.1007/BF01867921.
2
Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant.野生型 GluK1 型 kainate 受体及其 C 末端突变体的通道开放动力学机制。
Biochemistry. 2012 Jan 24;51(3):761-8. doi: 10.1021/bi201446z. Epub 2012 Jan 9.
3
Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor.人类野生型 GluK2 和 M867I 突变型 kainate 受体的通道开放动力学机制。
Biochemistry. 2010 Nov 2;49(43):9207-16. doi: 10.1021/bi100819v.
4
New renin inhibitors homologous with pepstatin.与胃蛋白酶抑制剂同源的新型肾素抑制剂。
Biochem J. 1981 Aug 1;197(2):465-71. doi: 10.1042/bj1970465.
5
Conformational changes during enzyme catalysis: role of water in the transition state.酶催化过程中的构象变化：水在过渡态中的作用。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3374-8. doi: 10.1073/pnas.77.6.3374.
6
In vitro effects of pure polychlorinated biphenyl isomers on the rabbit muscle lactate dehydrogenase.纯多氯联苯异构体对兔肌肉乳酸脱氢酶的体外作用。
Bull Environ Contam Toxicol. 1980 Oct;25(4):630-4. doi: 10.1007/BF01985582.
7
Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands.小牛胸腺的脱氧核苷酸聚合酶。IV. 金属配体对末端脱氧核苷酸转移酶的抑制作用
Proc Natl Acad Sci U S A. 1970 Apr;65(4):1041-8. doi: 10.1073/pnas.65.4.1041.
8
Peptidyl-puromycin synthesis on polyribosomes from Escherichia coli.来自大肠杆菌的多核糖体上肽基嘌呤霉素的合成。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):624-8. doi: 10.1073/pnas.69.3.624.
9
COMPT, a time-sharing program for nonlinear regression analysis of compartmental models of drug distribution.COMPT，一种用于药物分布房室模型非线性回归分析的分时程序。
J Pharmacokinet Biopharm. 1973 Apr;1(2):137-63. doi: 10.1007/BF01059627.
10
Structure-activity relationship of reversible cholinesterase inhibitors including paraquat.包括百草枯在内的可逆性胆碱酯酶抑制剂的构效关系。
Arch Toxicol. 1988 Aug;62(1):37-40. doi: 10.1007/BF00316254.