Lundberg B, Lövgren T, Heikius B
J Pharm Sci. 1979 May;68(5):542-5. doi: 10.1002/jps.2600680506.
The simultaneous solubilization of some androgens and estrogens in aqueous polysorbate 40, tetradecyltrimethylammonium bromide, and sodium lauryl sulfate was studied. The solubilizations of estradiol and testosterone were independent of each other in all three association colloids. However, if the estrogen component was ethinyl estradiol, the solubilization was dependent on the addition order. The estrogen precipitates more readily than testosterone in polysorbate 40 and tetradecyltrimethylammonium bromide, but the opposite is true in sodium lauryl sulfate. The simultaneous solubilizations of methyltestosterone or ethisterone with the estrogens tested were different from those of testosterone. The solubilization behavior of the steroids is discussed, starting with the pseudophase model and different solubilization loci. Results indicated that the free energy change of micellar binding, delta Gb, decreases with increased steroid polarity. The simultaneous solubilization cannot be predicted by delta Gb but may be explained by differences in the solubilization mechanism.
研究了一些雄激素和雌激素在聚山梨醇酯40、十四烷基三甲基溴化铵和十二烷基硫酸钠水溶液中的同时增溶情况。在所有三种缔合胶体中，雌二醇和睾酮的增溶作用相互独立。然而，如果雌激素成分是炔雌醇，增溶作用则取决于添加顺序。在聚山梨醇酯40和十四烷基三甲基溴化铵中，雌激素比睾酮更容易沉淀，但在十二烷基硫酸钠中情况相反。甲基睾酮或炔孕酮与所测试雌激素的同时增溶情况与睾酮不同。从假相模型和不同的增溶位点出发，讨论了类固醇的增溶行为。结果表明，胶束结合的自由能变化ΔGb随着类固醇极性的增加而降低。同时增溶不能用ΔGb来预测，但可以用增溶机制的差异来解释。
