Lövgren T, Heikius B, Lundberg B, Sjöblom L
J Pharm Sci. 1978 Oct;67(10):1419-22. doi: 10.1002/jps.2600671024.
The simultaneous solubilization of some estrogens and C21 steroids in aqueous polysorbate 40, tetradecyltrimethylammonium bromide, and sodium lauryl sulfate was studied. The less soluble estrogen estradiol was solubilized independently of the C21 steroids. The micellar solubilities of ethinyl estradiol and both corticosterone and hydrocortisone were independnet of the presence of each other while the solubility of 11alpha-hydroxyprogesterone was enhanced by ethinyl estradiol. The solubilizations of ethinyl estradiol and the two C21 steroids, progesterone and 21-hydroxyprogesterone, were dependent on each other so that a varying amount of the steroid solubilized first was precipitated by an excess of the second steroid. If saturated solutions of the two steroids were mixed, no precipitation occurred. A possible mechanism for the simultaneous solubilization of steroids and its relation to structure are discussed.
研究了一些雌激素和C21甾体在聚山梨醇酯40、十四烷基三甲基溴化铵和月桂醇硫酸酯钠水溶液中的同时增溶情况。溶解度较小的雌激素雌二醇的增溶与C21甾体无关。炔雌醇与皮质酮和氢化可的松的胶束溶解度相互独立，而11α-羟基孕酮的溶解度因炔雌醇而增强。炔雌醇与两种C21甾体孕酮和21-羟基孕酮的增溶相互依赖，以至于先增溶的不同量甾体被过量的第二种甾体沉淀出来。如果将两种甾体的饱和溶液混合，则不会发生沉淀。讨论了甾体同时增溶的可能机制及其与结构的关系。
