Straus S E, Sergeant A, Tigges M A, Raskas H J
J Virol. 1979 Feb;29(2):828-32. doi: 10.1128/JVI.29.2.828-832.1979.
At both early (3 h) and late (18 h) times after infection of KB cells with adenovirus 2, more than 90% of parental nuclear viral genomes exist as complexes which contain terminally linked proteins. Density shift experiments employing 5-bromo-2'-deoxyuridine indicate that these parental DNA molecules remain complexed with terminal proteins after DNA replication. The persistent linkage of proteins to the termini of intranuclear viral DNA suggests that these proteins have an essential role in adenovirus replication.
在用腺病毒2感染KB细胞后的早期（3小时）和晚期（18小时），超过90%的亲代核病毒基因组以含有末端连接蛋白的复合物形式存在。使用5-溴-2'-脱氧尿苷的密度转移实验表明，这些亲代DNA分子在DNA复制后仍与末端蛋白复合。蛋白质与核内病毒DNA末端的持续连接表明这些蛋白质在腺病毒复制中起重要作用。
