大鼠经皮质醇长期治疗后的下丘脑-垂体-肾上腺功能
Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol.
作者信息
Hodges J R, Sadow J
出版信息
Br J Pharmacol. 1969 Jul;36(3):489-95. doi: 10.1111/j.1476-5381.1969.tb08005.x.
Abstract
- Cortisol, administered subcutaneously every day for long periods, caused growth retardation, adrenal atrophy and impaired hypothalamo-pituitary-adrenal (HPA) function in the rat.2. The growth rate and the functional activity of the HPA system gradually returned to normal after steroid withdrawal.3. Normal adrenal sensitivity to corticotrophin returned more rapidly than normal pituitary corticotrophic function, suggesting that the initial impairment of HPA function was due both to reduced responsiveness of the adrenal gland to corticotrophin and failure of the pituitary gland to secrete the hormone.
摘要
长期每天皮下注射皮质醇会导致大鼠生长发育迟缓、肾上腺萎缩以及下丘脑 - 垂体 - 肾上腺（HPA）功能受损。
停用类固醇后，HPA系统的生长速率和功能活性逐渐恢复正常。
肾上腺对促肾上腺皮质激素的正常敏感性恢复得比垂体促肾上腺皮质功能更快，这表明HPA功能的最初损害既是由于肾上腺对促肾上腺皮质激素的反应性降低，也是由于垂体未能分泌该激素所致。
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本文引用的文献
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Suppression of the pituitary-ACTH response in man by administration of ACTH or cortisol.通过给予促肾上腺皮质激素（ACTH）或皮质醇来抑制人体垂体-促肾上腺皮质激素（ACTH）反应。
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Postoperative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone.
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