大鼠经倍他米松治疗后下丘脑-垂体-肾上腺皮质功能
Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone.
作者信息
Buckingham J C, Hodges J R
出版信息
Br J Pharmacol. 1976 Feb;56(2):235-9. doi: 10.1111/j.1476-5381.1976.tb07447.x.
Abstract
1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawl. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached 'supra-normal' levels. 4 The physiological significance and possible clinical relevance of the results are discussed.
摘要
1 用倍他米松治疗的大鼠下丘脑-垂体-肾上腺皮质（HPA）活性受到抑制。2 停用皮质类固醇后，HPA功能恢复正常。3 尽管促肾上腺皮质激素释放迅速恢复到基础水平，但对应激的正常促肾上腺皮质反应恢复存在延迟，只有在血浆促肾上腺皮质激素达到“超正常”水平后，正常肾上腺皮质功能才明显。4 讨论了这些结果的生理意义和可能的临床相关性。
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Interrelationships of pituitary and plasma corticotrophin and plasma corticosterone in adrenalectomized and stressed, adrenalectomized rats.肾上腺切除及应激的肾上腺切除大鼠垂体、血浆促肾上腺皮质激素和血浆皮质酮之间的相互关系
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