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单纯疱疹病毒感染的早期事件：一项放射自显影研究。

Early events in herpes simplex virus infection: a radioautographic study.

作者信息

Hummeler K, Tomassini N, Zajac B

出版信息

J Virol. 1969 Jul;4(1):67-74. doi: 10.1128/JVI.4.1.67-74.1969.

DOI:10.1128/JVI.4.1.67-74.1969
PMID:4309102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375839/
Abstract

The early events in herpes simplex virus infection were studied by means of radio-autography. The virus was rapidly taken up by the host cells and uncoated. Viral deoxyribonucleic acid (DNA) reached the nuclear sites of replication in 15 to 30 min after infection. The viral DNA occasionally associated with chromosomes or condensed chromatin but was more frequently found to be randomly distributed. Viral progeny appeared 3 hr after infection. These particles did not show any particular spatial relationship to the parental DNA. The morphological latent period lasted 2.5 hr.

摘要

通过放射自显影术研究了单纯疱疹病毒感染的早期事件。病毒迅速被宿主细胞摄取并脱壳。感染后15至30分钟，病毒脱氧核糖核酸（DNA）到达核复制位点。病毒DNA偶尔与染色体或浓缩染色质相关，但更常见的是随机分布。感染后3小时出现病毒后代。这些颗粒与亲代DNA没有任何特定的空间关系。形态学潜伏期持续2.5小时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/5c508f161280/jvirol00307-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/c4a2f9a17ac2/jvirol00307-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/c8c6c1ac0a69/jvirol00307-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/8bad28a9f8dc/jvirol00307-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/ce228c35e3a2/jvirol00307-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/d2e40d84dcb8/jvirol00307-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/48e566567c18/jvirol00307-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/f12a3cc6c8a0/jvirol00307-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/5c508f161280/jvirol00307-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/c4a2f9a17ac2/jvirol00307-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/c8c6c1ac0a69/jvirol00307-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/8bad28a9f8dc/jvirol00307-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/ce228c35e3a2/jvirol00307-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/d2e40d84dcb8/jvirol00307-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/48e566567c18/jvirol00307-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/f12a3cc6c8a0/jvirol00307-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a706/375839/5c508f161280/jvirol00307-0081-b.jpg

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本文引用的文献

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A sensitive and precise plaque assay for herpes virus.一种用于疱疹病毒的灵敏且精确的蚀斑测定法。
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THE ENTRY AND DISTRIBUTION OF HERPES VIRUS AND COLLOIDAL GOLD IN HELA CELLS AFTER CONTACT IN SUSPENSION.悬浮接触后疱疹病毒与胶体金在Hela细胞中的进入与分布
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Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. II. An ultrastructural study of viral penetration.单纯疱疹病毒和人巨细胞病毒在WI-38细胞中的复制。II. 病毒穿透的超微结构研究。
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Mechanism of intranuclear crystal formation of herpes simplex virus as revealed by the negative staining of thin sections.通过超薄切片负染揭示的单纯疱疹病毒核内晶体形成机制。
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