肝脏在维生素D代谢中的作用。
The role of the liver in the metabolism of vitamin D.
作者信息
Ponchon G, DeLuca H F
出版信息
J Clin Invest. 1969 Jul;48(7):1273-9. doi: 10.1172/JCI106093.
Abstract
The metabolism of vitamin D(3) has been studied after intravenous injection of 10 IU of [1,2-(3)H]-vitamin D(3) to vitamin D-deficient rats. The disappearance of the radioactivity from the plasma follows a very peculiar pattern characterized by an early rapid disappearance followed by a rebound of radioactivity before assuming still a third rather slow disappearance rate. The "rebound" phenomenon is concomitant with a rapid release of the radioactivity from the liver and is accounted for by the appearance of 25-hydroxycholecalciferol and other metabolites in the blood. It is postulated that the liver is the major site of transformation of vitamin D(3) into 25-hydroxycholecalciferol.
摘要
给维生素D缺乏的大鼠静脉注射10国际单位的[1,2-(3)H]-维生素D(3)后，对维生素D(3)的代谢进行了研究。血浆中放射性的消失呈现出一种非常特殊的模式，其特征是早期迅速消失，随后放射性出现反弹，之后才呈现出第三种相当缓慢的消失速率。“反弹”现象与放射性从肝脏的快速释放同时发生，并且血液中25-羟胆钙化醇和其他代谢产物的出现可以解释这一现象。据推测，肝脏是维生素D(3)转化为25-羟胆钙化醇的主要部位。
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