Embil J A, Krause V W, Haldane E V, Easterbrook K B, Crosby J M
Can Med Assoc J. 1969 Dec 13;101(12):32-40.
Two infants severely ill at birth as a result of congenital cytomegalovirus infection were born in Halifax, Nova Scotia, in April and July 1968. Both died within seven weeks. Clinical, pathological and virological studies including serology and electron microscopy were made both before and after death. Cytomegalovirus was isolated in tissue culture from urine specimens from both infants during life and from organ tissues, blood and ascitic fluid after death. Large inclusion-bearing cells mixed with the erythrocytes and leukocytes were seen within the lumina of pulmonary blood vessels. A brief general discussion is presented of the various clinical manifestations of congenital cytomegalovirus infection and of the different serum antibody patterns found in these two pairs of mothers and infants.
1968年4月和7月，在新斯科舍省哈利法克斯出生了两名因先天性巨细胞病毒感染而出生时病情严重的婴儿。两人均在七周内死亡。在死亡前后均进行了临床、病理和病毒学研究，包括血清学和电子显微镜检查。两名婴儿生前尿液标本以及死后器官组织、血液和腹水的组织培养中均分离出巨细胞病毒。在肺血管腔内可见与红细胞和白细胞混合的含大包涵体的细胞。本文简要概述了先天性巨细胞病毒感染的各种临床表现以及这两对母婴中发现的不同血清抗体模式。
