Quick C A, Foucar E, Dehner L P
Laryngoscope. 1979 Apr;89(4):550-60. doi: 10.1288/00005537-197904000-00003.
The clinical records and microscopic sections from 32 patients were reviewed in an attempt to correlate histopathologic features with clinical behavior. Three general clinical groups were identified on the basis of recurrence rates and extent of papillomatosis. In those lesions with the highest frequency of recurrences, epithelial atypia tended to be most pronounced. Although some of the lesions were quite disturbing, there was no evidence of invasive carcinoma. It remains unknown to date whether these cytologic abnormalities represent a neoplastic alteration or possibly atypia on the basis of rapid, but benign, cellular turnover. Further studies at our center and other institutions are necessary to test the proposed classification which, if validated, would provide a means of predicting the course of the disease and efficacy of the chosen management in these difficult cases.
回顾了32例患者的临床记录和显微切片，试图将组织病理学特征与临床行为相关联。根据复发率和乳头瘤病范围确定了三个一般临床组。在复发频率最高的那些病变中，上皮异型性往往最为明显。尽管有些病变相当令人不安，但没有浸润性癌的证据。迄今为止，尚不清楚这些细胞学异常是代表肿瘤性改变，还是可能基于快速但良性的细胞更新而出现的异型性。我们中心和其他机构需要进一步研究，以检验所提出的分类方法。如果该分类方法得到验证，将为预测这些疑难病例的疾病进程和所选治疗方法的疗效提供一种手段。
