Shahidi A, Ellner P D
Appl Microbiol. 1969 Nov;18(5):766-70. doi: 10.1128/am.18.5.766-770.1969.
Careful studies of the antibiotic susceptibilities of mixtures of bacteria likely to be encountered in clinical cultures have shown that the results obtained are completely unreliable. Mixtures of resistant and sensitive species appeared either as "resistant" or "sensitive" depending upon the organisms and the drug. A number of sensitive species gave reactions interpreted as resistant when tested in combination. Since reactions of bacterial mixtures are completely unpredictable, the authors emphasize that antibiotic susceptibility testing be limited to pure cultures.
对临床培养物中可能遇到的细菌混合物的抗生素敏感性进行的仔细研究表明，所获得的结果完全不可靠。耐药菌和敏感菌的混合物根据微生物和药物的不同，表现为“耐药”或“敏感”。一些敏感菌在联合测试时给出了被解释为耐药的反应。由于细菌混合物的反应完全不可预测，作者强调抗生素敏感性测试应仅限于纯培养物。
