葡萄糖对灌注大鼠肝脏中糖原合成酶、磷酸化酶及糖原沉积的影响。
Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver.
作者信息
Buschiazzo H, Exton J H, Park C R
出版信息
Proc Natl Acad Sci U S A. 1970 Feb;65(2):383-7. doi: 10.1073/pnas.65.2.383.
Abstract
An increase in the perfusate glucose concentration from near zero to about 11 mM increased glycogen synthesis in the perfused, isolated rat liver from zero to a value about half the maximum seen in the intact animal. Increased synthesis appeard to due not only to provision of substrate but also to conversion of glycogen synthetase to the active form and of glycogen phosphorylase to the inactive form. These glucose effects, which are apparently independent of changes in levels of hormones or adenosine 3':5'-cyclic phosphate, may be physiologically significant for control of the blood glucose level.
摘要
灌注液中葡萄糖浓度从接近零增加到约11 mM时，灌注的离体大鼠肝脏中的糖原合成从零增加到约为完整动物中所见最大值一半的值。合成增加似乎不仅是由于底物的提供，还由于糖原合成酶转变为活性形式以及糖原磷酸化酶转变为非活性形式。这些葡萄糖效应显然独立于激素或3':5'-环磷酸腺苷水平的变化，可能对血糖水平的控制具有生理意义。
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