Zuckerman A J, Taylor P E, Almeida J D
Br Med J. 1970 Jan 31;1(5691):262-4. doi: 10.1136/bmj.1.5691.262.
Examination of serum specimens from a patient with chronic active hepatitis proved negative to the Australia-SH antigen by immunodiffusion and by complement fixation. Because the sera were anticomplementary they were examined with the electron microscope, and virus-like structures similar to members of the coronavirus group were identified. The possible significance of this finding in human serum and its relation to mouse hepatitis virus are discussed.A sample of the serum pool containing the MS-1 agent was found negative when examined by immunodiffusion, complement fixation, and electron microscopy. The possible lack of immunological identity between infectious and serum hepatitis is discussed.
对一名慢性活动性肝炎患者的血清标本进行检测，结果通过免疫扩散和补体结合试验表明，澳大利亚- SH抗原呈阴性。由于这些血清具有抗补体性，因此用电子显微镜对其进行检测，结果发现了与冠状病毒属成员相似的病毒样结构。本文讨论了这一发现对人类血清可能具有的意义及其与小鼠肝炎病毒的关系。当通过免疫扩散、补体结合试验和电子显微镜对含有MS - 1因子的血清库样本进行检测时，结果呈阴性。本文还讨论了传染性肝炎和血清性肝炎之间可能缺乏免疫同一性的情况。
