人-鼠杂交细胞对冠状病毒229E的易感性定位在人类15号染色体上。
Coronavirus 229E susceptibility in man-mouse hybrids is located on human chromosome 15.
作者信息
Sakaguchi A Y, Shows T B
出版信息
Somatic Cell Genet. 1982 Jan;8(1):83-94. doi: 10.1007/BF01538652.
Abstract
Human coronavirus 229E, n enveloped, RNA-containing virus, causes respiratory illness in man and is serologically related to murine coronavirus JHM, which causes acute and chronic demyelination in rodents. 229E displays a species-specific host range restriction whose genetic basis was studied in human-mouse hybrids. 229E replicated in human WI-38 cells but not in three mouse cell lines tested (RAG, LM/TK-, and A9). Human coronavirus sensitivity (HCVS) was expressed as a dominant phenotype in hybrids, indicating that mouse cells do not actively suppress 229E replication. HCVS segregated concordantly with the human chromosome 15 enzyme markers mannose phosphate isomerase (MPI) and the muscle form of pyruvate kinase (PKM2), and analysis of hybrids containing an X/15 translocation [t(X;15)(p11;q11)] localized HCVS to the q11 leads to qter region of chromosome 15. HCVS might code for a specific surface receptor, allowing 229E to be absorbed to and received within the host cell.
摘要
人冠状病毒229E是一种有包膜、含RNA的病毒，可引起人类呼吸道疾病，在血清学上与鼠冠状病毒JHM相关，后者可导致啮齿动物出现急性和慢性脱髓鞘。229E表现出物种特异性的宿主范围限制，其遗传基础在人-鼠杂交细胞中进行了研究。229E能在人WI-38细胞中复制，但在三种测试的小鼠细胞系（RAG、LM/TK-和A9）中不能复制。人冠状病毒敏感性（HCVS）在杂交细胞中表现为显性表型，这表明小鼠细胞不会主动抑制229E的复制。HCVS与人类15号染色体酶标记物磷酸甘露糖异构酶（MPI）和肌肉型丙酮酸激酶（PKM2）呈一致分离，对含有X/15易位[t(X;15)(p11;q11)]的杂交细胞进行分析，将HCVS定位于15号染色体q11至qter区域。HCVS可能编码一种特异性表面受体，使229E能够被宿主细胞吸附并进入细胞内。
相似文献
1
Coronavirus 229E susceptibility in man-mouse hybrids is located on human chromosome 15.人-鼠杂交细胞对冠状病毒229E的易感性定位在人类15号染色体上。
Somatic Cell Genet. 1982 Jan;8(1):83-94. doi: 10.1007/BF01538652.
2
Human gene mapping using an X/autosome translocation.利用X/常染色体易位进行人类基因定位
Somatic Cell Genet. 1976 Mar;2(2):125-40. doi: 10.1007/BF01542626.
3
Seasonal human coronaviruses OC43, 229E, and NL63 induce cell surface modulation of entry receptors and display host cell-specific viral replication kinetics.季节性人类冠状病毒 OC43、229E 和 NL63 诱导细胞表面进入受体的调制，并显示宿主细胞特异性的病毒复制动力学。
Microbiol Spectr. 2024 Jul 2;12(7):e0422023. doi: 10.1128/spectrum.04220-23. Epub 2024 Jun 12.
4
Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of chromosome 15.
Somatic Cell Genet. 1977 Jan;3(1):47-60. doi: 10.1007/BF01550986.
5
Replication of mouse-tropic and xenotropic strains of murine leukemia virus in human x mouse hybrid cells.鼠白血病病毒的嗜小鼠株和异嗜性株在人 - 小鼠杂交细胞中的复制。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2642-5. doi: 10.1073/pnas.71.7.2642.
6
Suppression of replication of SV40 and polyoma virus in mouse-human hybrids.抑制SV40和多瘤病毒在小鼠-人杂种细胞中的复制。
Cell. 1977 May;11(1):25-33. doi: 10.1016/0092-8674(77)90314-2.
7
Confirmation of the synteny of the human genes for mannose phosphate isomerase and pyruvate kinase and of their assignment to chromosome 15.人类磷酸甘露糖异构酶和丙酮酸激酶基因的同线性确认及其在15号染色体上的定位。
Cytogenet Cell Genet. 1975;15(5):299-305. doi: 10.1159/000130527.
8
Genetics of cell surface receptors for bioactive polypeptides: binding of epidermal growth factor is associated with the presence of human chromosome 7 in human-mouse cell hybrids.生物活性多肽细胞表面受体的遗传学：表皮生长因子的结合与人鼠细胞杂种中人7号染色体的存在相关。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3600-4. doi: 10.1073/pnas.77.6.3600.
9
Assignment of the genes for human mitochondrial malate dehydrogenase to chromosome 7, for mannose phosphate isomerase and pyruvate kinase to chromosome 15, and, probably, for human esterase-D to chromosome 13 using man-mouse hybrids.
Cytogenet Cell Genet. 1975;14(3-6):353-7. doi: 10.1159/000130381.
10
Assignment of the genes for human mitochondrial malate dehydrogenase to chromosome 7, for mannose phosphate isomerase and pyruvate kinase to chromosome 15, and, probably, for human esterase-D to chromosome 13 using man-mouse hybrids.利用人-鼠杂种细胞将人类线粒体苹果酸脱氢酶基因定位于7号染色体，磷酸甘露糖异构酶和丙酮酸激酶基因定位于15号染色体，以及可能将人类酯酶-D基因定位于13号染色体。
Birth Defects Orig Artic Ser. 1975;11(3):183-7.
引用本文的文献
1
Birth seasonality studies in a large Prader-Willi syndrome cohort.大型普拉德-威利综合征队列中的出生季节性研究。
Am J Med Genet A. 2019 Aug;179(8):1531-1534. doi: 10.1002/ajmg.a.61263. Epub 2019 Jun 21.
2
Enhanced cell fusion activity in porcine epidemic diarrhea virus adapted to suckling mice.适应于乳鼠的猪流行性腹泻病毒的细胞融合活性增强。
Arch Virol. 2010 Dec;155(12):1989-95. doi: 10.1007/s00705-010-0790-1. Epub 2010 Sep 9.
3
Chromosomal location of the co-expressed human skeletal and cardiac actin genes.共表达的人类骨骼肌和心肌肌动蛋白基因的染色体定位。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1813-7. doi: 10.1073/pnas.81.6.1813.
4
Two human relaxin genes are on chromosome 9.两个人类松弛素基因位于9号染色体上。
EMBO J. 1984 Oct;3(10):2341-5. doi: 10.1002/j.1460-2075.1984.tb02136.x.
5
Polymorphic gene for human carbonic anhydrase II: a molecular disease marker located on chromosome 8.人类碳酸酐酶II的多态性基因：一个位于8号染色体上的分子疾病标志物。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4437-40. doi: 10.1073/pnas.80.14.4437.
6
Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.人单核细胞精氨酸丝氨酸蛋白酶抑制剂cDNA。序列、染色体定位及与纤溶酶原激活物抑制剂的同源性
J Exp Med. 1987 Jul 1;166(1):77-94. doi: 10.1084/jem.166.1.77.
7
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.编码一种T细胞和自然杀伤细胞特异性胰蛋白酶样丝氨酸蛋白酶的人类cDNA的克隆及染色体定位
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1184-8. doi: 10.1073/pnas.85.4.1184.
8
Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.人类碳酸酐酶III的核苷酸序列、组织特异性表达及染色体定位：人类CAIII基因与紧密连锁的CAI和CAII基因位于同一条染色体上。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9571-5. doi: 10.1073/pnas.83.24.9571.
9
Genes for two homologous G-protein alpha subunits map to different human chromosomes.两个同源G蛋白α亚基的基因定位于不同的人类染色体上。
Hum Genet. 1987 Nov;77(3):259-62. doi: 10.1007/BF00284481.
10
Human aminopeptidase N is a receptor for human coronavirus 229E.人氨肽酶N是人类冠状病毒229E的受体。
Nature. 1992 Jun 4;357(6377):420-2. doi: 10.1038/357420a0.
本文引用的文献
1
A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.一种引起弥散性脑脊髓炎且伴有髓鞘广泛破坏的鼠类病毒（JHM）：Ⅱ.病理学。
J Exp Med. 1949 Aug 31;90(3):195-212. doi: 10.1084/jem.90.3.195.
2
Receptor affinities as major determinants of enterovirus tissue tropisms in humans.受体亲和力是人类肠道病毒组织嗜性的主要决定因素。
Virology. 1961 Nov;15:312-26. doi: 10.1016/0042-6822(61)90363-4.
3
The mammalian cell-virus relationship. IV. Infection of naturally insusceptible cells with enterovirus ribonucleic acid.哺乳动物细胞与病毒的关系。IV. 肠道病毒核糖核酸对天然不敏感细胞的感染
J Exp Med. 1959 Jul 1;110(1):65-80. doi: 10.1084/jem.110.1.65.
4
Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients.从两名多发性硬化症患者的中枢神经系统组织中分离出两种冠状病毒。
Science. 1980 Aug 22;209(4459):933-4. doi: 10.1126/science.7403860.
5
Requirement of the human chromosome 11 long arm for replication of herpes simplex virus type 1 in nonpermissive Chinese hamster x human diploid fibroblast hybrids.1型单纯疱疹病毒在非允许性中国仓鼠×人二倍体成纤维细胞杂种中复制对人11号染色体长臂的需求
Somatic Cell Genet. 1981 Mar;7(2):171-91. doi: 10.1007/BF01567656.
6
Interferon production by human-mouse hybrid cells: dominant mouse control of superinduction and priming.人-鼠杂交细胞产生的干扰素：超诱导和启动的显性小鼠控制
J Gen Virol. 1980 Apr;47(2):489-95. doi: 10.1099/0022-1317-47-2-489.
7
Virologic studies of multiple sclerosis and other chronic and relapsing neurological diseases.多发性硬化症及其他慢性复发性神经疾病的病毒学研究
Prog Med Virol. 1974;18(0):214-28.
8
Viral infections and demyelinating diseases.病毒感染与脱髓鞘疾病。
N Engl J Med. 1973 May 24;288(21):1103-10. doi: 10.1056/NEJM197305242882106.
9
Pathogenesis of demyelination induced by a mouse hepatitis.小鼠肝炎诱导的脱髓鞘发病机制。
Arch Neurol. 1973 May;28(5):298-303. doi: 10.1001/archneur.1973.00490230034003.
10
The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21.人类干扰素诱导的抗病毒蛋白基因与吲哚酚氧化酶-B性状与G-21染色体的连锁。
J Exp Med. 1973 Feb 1;137(2):317-30. doi: 10.1084/jem.137.2.317.
Zotero 插件