一种干扰素诱导剂对流感病毒的作用。
The effect of an interferon inducer on influenza virus.
作者信息
Hill D A, Baron S, Chanock R M
出版信息
Bull World Health Organ. 1969;41(3):689-93.
Abstract
The double-stranded complex of polyriboinosinic acid and polyribocytidilic acid (poly I.poly C) was shown to inhibit effectively the infection of human cells with 4 common human respiratory pathogens-influenza A2, rhinovirus 13, respiratory syncytial and parainfluenza-1 viruses. This protection was observed with levels of poly I.poly C which did not induce the release of detectable amounts of interferon. Mice could be protected from pulmonary influenza A2 infections by intranasal instillation of poly I.poly C before challenge with virus. Administration of poly I.poly C directly to the respiratory tract was found superior to systemic administration in the case of the pulmonary infection studied.
摘要
聚肌苷酸和聚胞苷酸的双链复合物（聚肌胞苷酸）已被证明能有效抑制4种常见人类呼吸道病原体——甲型流感病毒2型、鼻病毒13型、呼吸道合胞病毒和副流感病毒1型对人类细胞的感染。在聚肌胞苷酸的浓度水平下观察到了这种保护作用，该浓度水平不会诱导释放可检测量的干扰素。在用病毒攻击之前，通过鼻腔滴注聚肌胞苷酸可保护小鼠免受甲型流感病毒2型肺部感染。在所研究的肺部感染病例中，发现将聚肌胞苷酸直接施用于呼吸道优于全身给药。
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