一种新型戊二酰亚胺抗生素9-甲基链霉咪唑酮的抗病毒及诱导干扰素活性
Antiviral and interferon-inducing activity of a new glutarimide antibiotic, 9-methylstreptimidone.
作者信息
Saito N, Suzuki F, Sasaki K, Ishida N
出版信息
Antimicrob Agents Chemother. 1976 Jul;10(1):14-9. doi: 10.1128/AAC.10.1.14.
Abstract
The antiviral effect of 9-methylstreptimidone (9-MS) was examined in mice infected with mouse-adapted influenza A(2) (H(2)N(2)) virus. Both a single and continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison between the minimal effective and the 50% lethal dose gave a therapeutic index of 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. After a single intraperitoneal administration of 9-MS, a highly potent virus-inhibitory factor was detected in the lungs (10 h later) and the sera (16 h later) of uninfected mice, which was assumed to be an interferon on the basis of the biological characteristics. These results suggest that the protective activity of the antibiotic is due to interferon induction in mice.
摘要
研究了9-甲基链霉咪唑酮（9-MS）对感染鼠适应甲型流感病毒A（2）（H2N2）的小鼠的抗病毒作用。单次和连续预防性给予9-MS均可保护小鼠免受病毒感染，最小有效剂量与50%致死剂量的比较得出治疗指数为60。然而，感染后开始治疗时，未显示出抗病毒作用。单次腹腔注射9-MS后，在未感染小鼠的肺（10小时后）和血清（16小时后）中检测到一种高效病毒抑制因子，根据其生物学特性推测为干扰素。这些结果表明，该抗生素的保护活性是由于在小鼠中诱导产生了干扰素。
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