Klein D C, Weller J L
Science. 1970 Sep 11;169(3950):1093-5. doi: 10.1126/science.169.3950.1093.
The activity of N-acetyltransferase in the rat pineal gland is more than 15 times higher at night than during the day. This circadian rhythm persists in complete darkness, or in blinded animals, and is suppressed in constant lighting. The N-acetyltransferase rhythm is 180 degrees out of phase with the serotonin rhythm and is similar to the norepinephrine and melatonin rhythms. Experiments in vitro indicate that norepinephrine, not serotonin, regulates the activity of N-acetyl-transferase through a highly specific receptor.
大鼠松果体中N - 乙酰转移酶的活性在夜间比白天高出15倍以上。这种昼夜节律在完全黑暗或失明动物中持续存在，而在持续光照下受到抑制。N - 乙酰转移酶节律与血清素节律相差180度，与去甲肾上腺素和褪黑激素节律相似。体外实验表明，去甲肾上腺素而非血清素通过高度特异性受体调节N - 乙酰转移酶的活性。
