Szalay J, Temesvári P, Bara D
Morphol Igazsagugyi Orv Sz. 1979 Jan;19(1):15-22.
A single-approximately LD50-dosis of the 3-AP given to white rats following the unilateral ligature of the carotid artery in almost 70 percent of the animals caused hydropic-vacuolic degeneration and cell necrosis in the nucleus ruber. Similar changes were quite infrequent in the mesenphalic nuclei. The regressiv changes can be prevented by nicotinamid. When smaller doses are given they do not occur at all. Electronmicroscopic findings help to explain some aspects of the pathogenesis of these rather selective changes.
在给大鼠单侧结扎颈动脉后，给予单次约半数致死量的3-氨基吡啶，几乎70%的动物红核出现水样空泡变性和细胞坏死。中脑核团中类似变化相当少见。烟酰胺可预防这些退行性变化。给予较小剂量时则根本不会出现这些变化。电子显微镜检查结果有助于解释这些相当有选择性的变化的发病机制的某些方面。
