Anders R F, Hogg D M, Jago G R
Appl Microbiol. 1970 Apr;19(4):608-12. doi: 10.1128/am.19.4.608-612.1970.
The formation of hydrogen peroxide by group N streptococci was found to occur through the action of a reduced nicotinamide adenine dinucleotide (NADH) oxidase which catalyzed the oxidation of NADH by molecular oxygen. The enzyme was activated by flavine adenine dinucleotide. Whereas some of the hydrogen peroxide formed was removed through the action of an NADH peroxidase, sufficient accumulated in media to inhibit the growth, respiration, and viability of these organisms. The amount of hydrogen peroxide which accumulated varied among strains, and this variation could be related to differences in the properties of the NADH oxidase present.
发现N群链球菌产生过氧化氢是通过一种还原型烟酰胺腺嘌呤二核苷酸(NADH)氧化酶的作用,该酶催化NADH被分子氧氧化。该酶被黄素腺嘌呤二核苷酸激活。虽然部分生成的过氧化氢通过NADH过氧化物酶的作用被清除,但仍有足够的过氧化氢在培养基中积累,从而抑制这些微生物的生长、呼吸和活力。不同菌株积累的过氧化氢量有所不同,这种差异可能与所存在的NADH氧化酶特性的差异有关。