Van Thiel D H, Gavaler J S, Smith W I, Paul G
N Engl J Med. 1979 May 3;300(18):1012-5. doi: 10.1056/NEJM197905033001803.
We studied the effect of cimetidine therapy (1200 mg per day by mouth for nine weeks) on the hypothalamic-pituitary-gonadal axis of seven men. There was a 43 per cent mean reduction in sperm count after therapy. The luteinizing hormone response to luteinizing hormone releasing factor was also reduced, and a statistically significnat rise in plasma testosterone occurred, although it was less than that before therapy. Gonadotropin responses to provocative clomiphene stimulation were inadequate when compared with those of controls. Cimetidine did not affect the responses of thyroid-stimulating hormone, prolactin, growth hormone and thyroxine to thyrotropin releasing factor. Caution is advisable in administration of cimetidine for prolonged periods to young men.
我们研究了西咪替丁疗法（每日口服1200毫克，持续9周）对7名男性下丘脑-垂体-性腺轴的影响。治疗后精子计数平均降低了43%。黄体生成素对黄体生成素释放因子的反应也降低了，血浆睾酮出现了统计学上显著的升高，尽管低于治疗前。与对照组相比，促性腺激素对克罗米芬激发刺激的反应不足。西咪替丁不影响促甲状腺激素、催乳素、生长激素和甲状腺素对促甲状腺激素释放因子的反应。对于年轻男性，长时间使用西咪替丁时应谨慎。
