西咪替丁对男性性腺功能的影响。
Effect of cimetidine on gonadal function in man.
作者信息
Wang C, Lai C L, Lam K C, Yeung K K
出版信息
Br J Clin Pharmacol. 1982 Jun;13(6):791-4. doi: 10.1111/j.1365-2125.1982.tb01867.x.
Abstract
1 To study the effect of cimetidine on gonadal function in man, eleven male subjects with chronic duodenal ulcer were given cimetidine orally at a dosage of 1000 mg per day 3 months and 400 mg nocte for the subsequent 3 months. 2 Testosterone levels were found to be elevated during therapy when compared to pre- and post-treatment periods. Serum LH remained unchanged but FSH was increased during therapy. In five out of eleven subjects serum PRL levels were increased. Mean sperm count was lower during cimetidine therapy when compared with that after drug withdrawal. The motility and morphology of the spermatozoa were not affected.
摘要
- 为研究西咪替丁对男性性腺功能的影响，对11名患有慢性十二指肠溃疡的男性受试者口服西咪替丁，前3个月每天剂量为1000毫克，随后3个月每晚剂量为400毫克。2. 与治疗前和治疗后时期相比，治疗期间睾酮水平升高。血清促黄体生成素（LH）保持不变，但治疗期间促卵泡生成素（FSH）升高。11名受试者中有5名血清催乳素（PRL）水平升高。与停药后相比，西咪替丁治疗期间平均精子计数较低。精子的活力和形态未受影响。
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本文引用的文献
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Monotropic increase of serum FSH correlated with low sperm count in young men with idiopathic oligospermia and aspermia.在患有特发性少精子症和无精子症的年轻男性中，血清促卵泡激素（FSH）的单向升高与精子数量少相关。
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Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.男性促黄体生成素的间歇性分泌。脉冲分析、临床解读及生理机制
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Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man.存在一种影响男性促卵泡激素分泌的特定生精小管因子的证据。
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Letter: Breast changes in males on cimetidine.信函：西咪替丁治疗男性患者时的乳房变化
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