Bradley P, Berry M
Neuropathol Appl Neurobiol. 1979 Jan-Feb;5(1):9-16. doi: 10.1111/j.1365-2990.1979.tb00609.x.
A quantitative analysis was made of alterations in the dentritic organisation of Purkinje cells in the cerebellum of the adult rat following the administration of the degranulating agent, thiophene. This substance completely eliminated the granule cell population in a number of regions of cerebellar cortex. Purkinje cell dentdritic trees in these regions were markedly reduced in size when compared with control cells and provided evidence for a non-random loss of dentritic segments. Other dendritic abnormalities were noted. These results were discussed in relation to current theories of neuronal maintenance, and the feasibility of using toxic degranulating agents, such as thiophene, was considered.
对成年大鼠小脑浦肯野细胞树突组织在给予脱颗粒剂噻吩后的变化进行了定量分析。该物质完全消除了小脑皮质多个区域的颗粒细胞群。与对照细胞相比，这些区域的浦肯野细胞树突明显变小，并为树突节段的非随机丢失提供了证据。还发现了其他树突异常。结合当前关于神经元维持的理论对这些结果进行了讨论，并考虑了使用噻吩等有毒脱颗粒剂的可行性。
