Lewandowska E, Kujawa M, Jedrzejewska A
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw.
Folia Neuropathol. 1994;32(1):61-4.
The morphometric approach to evaluation of some organelles of the rat cerebellar Purkinje cells after chronic ethanol intoxication according to the previously elaborated model (Jedrzejewska et al. 1990) was employed. In the experimental rats volumes of both the perikarya and nuclei in the Purkinje cells significantly increased. The quantitative, morphometric changes of both rough and smooth endoplasmic reticulum demonstrated, that in the perikarya and dendrites of the Purkinje cells the volume of rough endoplasmic reticulum decreased and the volume of smooth endoplasmic reticulum increased. The number of lipofuscin granules in the perikarya increased whereas the counts of microtubules per unit area in dendrites decreased. The statistical evaluation of parameters describing mitochondria and Golgi apparatus in ethanol-intoxicated animals did not show significant differences as compared with the control ones.
根据先前制定的模型（Jedrzejewska等人，1990年），采用形态计量学方法评估慢性乙醇中毒后大鼠小脑浦肯野细胞的一些细胞器。在实验大鼠中，浦肯野细胞的胞体和细胞核体积均显著增加。粗面和滑面内质网的定量形态计量学变化表明，在浦肯野细胞的胞体和树突中，粗面内质网体积减小，滑面内质网体积增加。胞体中脂褐素颗粒的数量增加，而树突中单位面积微管的数量减少。与对照组相比，对乙醇中毒动物中线粒体和高尔基体参数的统计评估未显示出显著差异。
