“霍乱样腹泻”病例中肿瘤及血液中异常促胰液素样和胃泌素样活性的生物测定证据。
Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of "choleraic diarrhoea".
作者信息
Cleator I G, Thomson C G, Sircus W, Coombes M
出版信息
Gut. 1970 Mar;11(3):206-11. doi: 10.1136/gut.11.3.206.
Methods for bio-assay of secretin-like humoral agents in both cat and dog are described. Bio-assay of tumour extracts and of plasma from patients with the pancreatic choleraic syndrome are described. The first patient was found to have choleretic and secretinlike activity in an extract of her pancreatic islet cell tumour and gastrin-like activity in her plasma. The second patient was found to have both secretin and gastrin-like activity in her plasma, as well as choleretic activity. It is concluded that at least part of the profuse, watery electrolyte diarrhoea of the ;pancreatic cholera' syndrome associated with peptide-secreting adenoma of the pancreas is likely to be a reflection of the excessive production of secretin, as well as of gastrin, and possibly also of a choleretic agent.
本文描述了猫和狗中促胰液素样体液因子的生物测定方法。还描述了肿瘤提取物和胰性霍乱综合征患者血浆的生物测定。发现首例患者的胰岛细胞瘤提取物具有利胆和促胰液素样活性，其血浆具有胃泌素样活性。发现第二例患者的血浆具有促胰液素和胃泌素样活性以及利胆活性。得出的结论是，与胰腺肽分泌性腺瘤相关的“胰性霍乱”综合征中至少部分大量水样电解质腹泻可能反映了促胰液素、胃泌素以及可能还有一种利胆剂的过度产生。
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