Malacco E, Iacono G, Risso F
Minerva Med. 1979 Feb 18;70(8):575-81.
The clinical course, persistance of HBs antigen, and the liver biopsy morphological picture were evaluated in 40 patients with acute viral hepatitis, type B. In 34 cases, the disease ran a satisfactory course and clinical cure was corroborated histologically. In 4 cases, onset was particularly severe and the disease ran a long course. Here the immunological test for HBs antigen was still positive 8 weeks after the disease began, while a biopsy at 4 months showed a morphological picture similar to that of acute hepatitis. Lastly, two cases with a protracted clinical course displayed persistent HBs antigen positivity one year after the acute episode, with a histological finding of persistent hepatitis and cirrhosis of the liver respectively.
对40例乙型急性病毒性肝炎患者的临床病程、乙肝表面抗原（HBs抗原）持续存在情况及肝活检形态学表现进行了评估。34例患者病情进展顺利，临床治愈得到了组织学证实。4例患者起病特别严重，病程较长。这些患者在发病8周后，HBs抗原免疫检测仍为阳性，而在4个月时进行的活检显示形态学表现与急性肝炎相似。最后，2例病程迁延的患者在急性发作1年后HBs抗原持续呈阳性，组织学检查分别发现持续性肝炎和肝硬化。
