Sundaram C, Reddy C R, Ramana G V, Benerjea S, Venkataratnam G, Kumari G S, Reddy B S, Bhaskaran C S
Department of Pathology, Andhra Medical College, Visakhapatnam, India.
Indian J Pathol Microbiol. 1990 Oct;33(4):334-8.
This study is aimed at finding the association of hepatocellular carcinoma and cirrhosis with hepatitis B surface antigen in a particular geographical area, Andhra Pradesh State in South India. In total, 206 cases of autopsy livers were studied for the presence of hepatitis B surface antigen by orcein staining. Of the 114 cases of cirrhosis 67.54% were positive for the antigen. There were 13 cases of macronodular, 55 cases of mixed and 46 cases of micronodular cirrhosis. The antigen positivity was 100%, 98.7% and 21.74% respectively. The difference in positivity between micronodular and the other two types of cirrhosis was statistically significant (P less than 0.01). Of the 58 cases of hepatocellular carcinoma, 50 were associated with cirrhosis. In 80% of these cases, hepatitis B surface antigen was demonstrated, whereas 75% of cases of hepatocellular carcinoma not associated with cirrhosis, were positive for hepatitis B surface antigen. The geographical importance of these findings was discussed.
本研究旨在探寻印度南部安得拉邦这一特定地理区域内肝细胞癌及肝硬化与乙肝表面抗原之间的关联。总共对206例尸检肝脏进行了orcein染色，以检测乙肝表面抗原的存在情况。在114例肝硬化病例中，67.54%抗原呈阳性。其中有13例大结节性肝硬化、55例混合性肝硬化和46例小结节性肝硬化。抗原阳性率分别为100%、98.7%和21.74%。小结节性肝硬化与其他两种类型肝硬化之间的阳性率差异具有统计学意义（P小于0.01）。在58例肝细胞癌病例中，50例与肝硬化相关。在这些病例中，80%检测出乙肝表面抗原，而在未与肝硬化相关的肝细胞癌病例中，75%乙肝表面抗原呈阳性。文中讨论了这些发现的地理意义。
