胆红素尿苷二磷酸葡萄糖醛酸基转移酶向酶缺陷型大鼠的转移。
Transfer of bilirubin uridine diphosphate-glucuronyltransferase to enzyme-deficient rats.
作者信息
Rugstad H E, Robinson S H, Yannoni C, Tashjian A H
出版信息
Science. 1970 Oct 30;170(3957):553-5. doi: 10.1126/science.170.3957.553.
PMID:4319199
Abstract
Cells from a clonal strain (MH(1)C(1)) of rat hepatoma were transplanted subcutaneously into two homozygous Gunn rats, which are jaundiced because the enzyme bilirubin uridine diphosphate-glucuronyltransferase is absent from the liver. Because of the enzyme activity present in the transplanted cells, the recipient rats developed the capacity to conjugate bilirubin and reverted in large part to a normal pattern of bilirubin excretion.
摘要
将大鼠肝癌克隆株（MH(1)C(1)）的细胞皮下移植到两只纯合子冈恩大鼠体内，这两只大鼠因肝脏中缺乏胆红素尿苷二磷酸 - 葡萄糖醛酸转移酶而黄疸。由于移植细胞中存在该酶活性，受体大鼠产生了结合胆红素的能力，并且在很大程度上恢复到正常的胆红素排泄模式。
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