Wayte D M, Stewart J B, McKenzie C G
J Clin Pathol. 1970 Jul;23(5):414-22. doi: 10.1136/jcp.23.5.414.
A composite malignant tumour arising in the breast of an elderly woman is described. The cystic tumour containing areas of squamous metaplasia, bone formation, adenocarcinoma, and osteosarcoma was surrounded by the typical changes of mammary dysplasia (fibroadenosis). The classification and acceptance of such tumours is highly debatable. There is no one acceptable classification of breast sarcomas and hence the prognosis of such neoplasms, particularly those containing heterologous tissues, is poorly defined. Evidence is presented in support of such composite tumours as being definite entities which arise from the closely associated epithelial and mesenchymal components of the breast simultaneously.
本文描述了一位老年女性乳房中出现的复合性恶性肿瘤。该囊性肿瘤包含鳞状化生、骨形成、腺癌和骨肉瘤区域，周围伴有乳腺发育异常（纤维腺病）的典型改变。此类肿瘤的分类及是否被认可极具争议性。目前尚无一种被广泛接受的乳腺肉瘤分类方法，因此这类肿瘤，尤其是那些包含异源性组织的肿瘤，其预后难以明确界定。本文提供的证据支持此类复合性肿瘤是由乳腺紧密相关的上皮和间充质成分同时发生而形成的明确实体。
