牛瘟病毒的免疫抑制作用。
The immunodepressive effect of rinderpest virus.
作者信息
Penhale W J, Pow I A
出版信息
Clin Exp Immunol. 1970 Apr;6(4):627-32.
The effect of rinderpest virus on the immune response of rabbits to subsequently administered chicken erythrocytes has been investigated as a means of assessing the effects of this virus on general immunological responsiveness. A significant depression of the primary response was consistently found in those rabbits which became febrile following viral inoculation. In some cases this inhibitory effect extended to the secondary immune response to the same antigen given approximately 3 weeks after the virus. The degree of immune depression did not appear to be related to the concentration of virus administered. These observations are discussed in relation to the pathogenesis of Rinderpest and other myxovirus infections.
作为评估牛瘟病毒对一般免疫反应性影响的一种手段，已经研究了牛瘟病毒对兔子随后接种鸡红细胞的免疫反应的影响。在接种病毒后发热的兔子中，始终发现其初次反应有明显的抑制。在某些情况下，这种抑制作用延伸至对大约在病毒接种后3周给予的相同抗原的二次免疫反应。免疫抑制的程度似乎与所接种病毒的浓度无关。结合牛瘟和其他黏液病毒感染的发病机制对这些观察结果进行了讨论。
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