A method for the estimation of the fraction of a precursor that is converted to a metabolite in rat in vivo with phenacetin and acetaminophen. - Suppr | 超能文献

A method for the estimation of the fraction of a precursor that is converted to a metabolite in rat in vivo with phenacetin and acetaminophen.

作者信息

Pang K S, Strobl K, Gillette J R

出版信息

Drug Metab Dispos. 1979 Nov-Dec;7(6):366-72.

PMID:43221

Abstract

摘要

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A method for the estimation of the fraction of a precursor that is converted to a metabolite in rat in vivo with phenacetin and acetaminophen.

Drug Metab Dispos. 1979 Nov-Dec;7(6):366-72.

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Phenacetin concentrations in portal and hepatic venous blood in man.

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6

Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat.

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Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.3-甲基胆蒽预处理对大鼠体内非那西丁生物利用度的影响。

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Effect of age on the disposition and tissue clearances of fluorinated pyrimidines in rats.年龄对氟嘧啶类药物在大鼠体内处置和组织清除率的影响。

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Metabolite pharmacokinetics: the area under the curve of metabolite and the fractional rate of metabolism of a drug after different routes of administration for renally and hepatically cleared drugs and metabolites.代谢物药代动力学：肾清除和肝清除药物及代谢物经不同给药途径给药后代谢物的曲线下面积和药物代谢分数率。

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Drug metabolite concentration-time profiles: influence of route of drug administration.药物代谢物浓度-时间曲线：给药途径的影响

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