Scolnick E, Rands E, Aaronson S A, Todaro G J
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1789-96. doi: 10.1073/pnas.67.4.1789.
The RNA-dependent DNA polymerase(s) in murine leukemia, murine mammary tumor, and avian myeloblastosis viruses require maganese for optimal activity. The transcription of added synthetic polyribonucleotides is greatly enhanced when manganese is used in place of magnesium. A soluble RNA-dependent DNA polymerase activity has been released from murine leukemia particles in the presence of manganese and high detergent concentrations. Two RNA viruses, visna virus of sheep and a primate syncytial virus, not known to have tumor-producing ability, also contain the polymerase.
鼠白血病病毒、鼠乳腺肿瘤病毒和禽成髓细胞瘤病毒中的RNA依赖性DNA聚合酶需要锰来实现最佳活性。当使用锰代替镁时，添加的合成多聚核糖核苷酸的转录会大大增强。在存在锰和高浓度去污剂的情况下，可溶性RNA依赖性DNA聚合酶活性已从鼠白血病颗粒中释放出来。两种RNA病毒，即绵羊的维斯纳病毒和一种灵长类合胞体病毒，虽然未知具有致瘤能力，但也含有这种聚合酶。
