鼠伤寒沙门氏菌对D-甘露醇的利用
D-Mannitol utilization in Salmonella typhimurium.
作者信息
Berkowitz D
出版信息
J Bacteriol. 1971 Jan;105(1):232-40. doi: 10.1128/jb.105.1.232-240.1971.
Abstract
A biochemical and genetic analysis of d-mannitol metabolism in Salmonella typhimurium indicates that d-mannitol is phosphorylated by the phosphoenolpyruvate-dependent phosphotransferase system. d-Mannitol-1-phosphate is converted to d-fructose-6-phosphate by mannitol-1-phosphate dehydrogenase. Two classes of mannitol mutants are described. Both map at about 115 min on the Salmonella chromosome. Mutants missing mannitol-1-phosphate dehydrogenase activity are mannitol sensitive; i.e., either growth is inhibited or the cells are lysed in the presence of mannitol. In a strain missing adenyl cyclase activity, the mannitol genes require exogenous cyclic adenosine-3',5'-monophosphate for expression.
摘要
对鼠伤寒沙门氏菌中d-甘露醇代谢的生化和遗传分析表明，d-甘露醇通过磷酸烯醇丙酮酸依赖性磷酸转移酶系统进行磷酸化。d-甘露醇-1-磷酸通过甘露醇-1-磷酸脱氢酶转化为d-果糖-6-磷酸。描述了两类甘露醇突变体。两者都位于沙门氏菌染色体上约115分钟处。缺失甘露醇-1-磷酸脱氢酶活性的突变体对甘露醇敏感；即，在甘露醇存在下生长受到抑制或细胞裂解。在缺失腺苷酸环化酶活性的菌株中，甘露醇基因需要外源环腺苷-3',5'-单磷酸才能表达。
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