Holmes R E
Plast Reconstr Surg. 1979 May;63(5):626-33. doi: 10.1097/00006534-197905000-00004.
The hypothesis that incomplete resorption of osteons in an autogenous cortical bone graft may limit its replacement by new bone regeneration was explored by implanting a hydroxyapatite replica of a coral skeletal structure into bone gaps. This implant contained channels and interconnections similar to those in osteon-evacuated bone grafts. In 6 implanted mandibular defects in dogs, two of which were examined at two, 4, and 6 months, 11 percent, 46 percent, and 88 percent of the implant areas were filled with regenerated bone. The regenerated bone was a woven type at two months, but changed to a lamellar type by 6 months. In two implanted defects examined at 12 months, biodegradation of 29 percent of the implant had occurred. The bone regeneration was physiological, the implant was biocompatible, and the biodegradation began after the bone had regenerated.
通过将珊瑚骨骼结构的羟基磷灰石复制品植入骨间隙，探讨了自体皮质骨移植中骨单位不完全吸收可能会限制其被新骨再生替代这一假说。该植入物包含与骨单位排空的骨移植中类似的通道和互连结构。在6只植入下颌骨缺损的犬中，其中2只在2个月、4个月和6个月时进行检查，植入物区域分别有11%、46%和88%被再生骨填充。2个月时再生骨为编织型，但到6个月时转变为板层型。在12个月时检查的2个植入缺损中，29%的植入物发生了生物降解。骨再生是生理性的，植入物具有生物相容性，且生物降解在骨再生后开始。
