Gibberd F B, Navab F, Smith C L
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):11-3. doi: 10.1136/jnnp.34.1.11.
Nine patients with severe myasthenia gravis, including ocular symptoms, who did not respond to anticholinesterase therapy were given prolonged courses of corticotrophin. In all patients except one there was an initial deterioration, sometimes necessitating assisted respiration, followed by a marked improvement which persisted for many weeks and occasionally months. It is concluded that corticotrophin should be continued for at least two weeks as the onset of the remission might be delayed. Repeated courses or small maintenance doses prolonged the remission. Fluid retention and hypokalaemia were common unwanted effects but necessitated stopping the treatment in only one patient.
9例伴有眼部症状的重症肌无力患者，对抗胆碱酯酶治疗无反应，接受了长期促肾上腺皮质激素疗程治疗。除1例患者外，所有患者均出现病情最初恶化，有时需要辅助呼吸，随后病情显著改善，持续数周，偶尔数月。得出的结论是，促肾上腺皮质激素应持续使用至少两周，因为缓解期可能会延迟出现。重复疗程或小剂量维持治疗可延长缓解期。液体潴留和低钾血症是常见的不良反应，但仅1例患者因此停止治疗。
