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重症肌无力患者使用促肾上腺皮质激素的获益。

Benefit from adrenocorticotrophin in myasthenia gravis.

作者信息

Liversedge L A, Yuill G M, Wilkinson I M, Hughes J A

出版信息

J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):412-5. doi: 10.1136/jnnp.37.4.412.

DOI:10.1136/jnnp.37.4.412
PMID:4365243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494671/
Abstract

Twenty-one of 29 patients suffering from myasthenia gravis derived benefit from a short intensive course of adrenocorticotrophin (ACTH). The mean duration of benefit was approximately six months. The best results were obtained in patients with a short history of myasthenia. Transient deterioration during the course of injections was encountered in some cases but necessitated assisted respiration only in patients with severe generalized weakness before treatment.

摘要

29例重症肌无力患者中有21例从短期强化促肾上腺皮质激素(ACTH)治疗中获益。获益的平均持续时间约为6个月。重症肌无力病史较短的患者取得了最佳疗效。部分病例在注射过程中出现短暂病情恶化,但仅在治疗前有严重全身无力的患者中需要辅助呼吸。

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Benefit from adrenocorticotrophin in myasthenia gravis.重症肌无力患者使用促肾上腺皮质激素的获益。
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):412-5. doi: 10.1136/jnnp.37.4.412.
2
Results with ACTH and spironolactone in severe cases of myasthenia gravis.促肾上腺皮质激素和螺内酯治疗重症肌无力严重病例的结果。
Acta Neurol Scand Suppl. 1965;13 Pt 2:463-71. doi: 10.1111/j.1600-0404.1965.tb01915.x.
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Corticotropin in generalized myasthenia gravis. Effect of short, intensive courses.促肾上腺皮质激素在全身型重症肌无力中的应用。短期强化疗程的效果。
JAMA. 1966 Nov 14;198(7):703-7.
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Maintenance adrenocorticotropic hormone (ACTH) treatment in myasthenia gravis.
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Treatment of myasthenia gravis with adrenocorticotropic hormone (ACTH): massive short-term and maintenance treatment.促肾上腺皮质激素(ACTH)治疗重症肌无力:大剂量短期及维持治疗
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Treatment of severe myasthenia gravis with large doses of ACTH.大剂量促肾上腺皮质激素治疗重症肌无力
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[Treatment of myasthenia with adrencorticotrophins (ACTH and Synacthen). Apropos of 100 treatments in 25 patients].[用促肾上腺皮质激素(促肾上腺皮质激素和辛纳克坦)治疗重症肌无力。关于对25例患者进行的100次治疗]
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Ann N Y Acad Sci. 1976;274:577-95. doi: 10.1111/j.1749-6632.1976.tb47717.x.

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A case of myasthenia gravis treated with steroids: some suggestions for the mechanisms underlying their effect.一例用类固醇治疗的重症肌无力病例:关于其作用机制的一些建议
Postgrad Med J. 1977 Jun;53(620):321-4. doi: 10.1136/pgmj.53.620.321.
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Value of exchangeable electrolyte measurement in the treatment of myasthenia gravis.可交换电解质测量在重症肌无力治疗中的价值。
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本文引用的文献

1
Effect of adrenocorticotropic hormone (ACTH) and cortisone administration in patients with myasthenia gravis and report of onset of myasthenia gravis during prolonged cortisone administration.促肾上腺皮质激素(ACTH)和可的松给药对重症肌无力患者的影响以及长期使用可的松期间重症肌无力发病情况的报告。
Bull Johns Hopkins Hosp. 1952 Aug;91(2):124-36.
2
Effects of administration of the adrenocorticotropic hormone on patients with myasthenia gravis.促肾上腺皮质激素给药对重症肌无力患者的影响。
AMA Arch Neurol Psychiatry. 1951 Aug;66(2):163-70. doi: 10.1001/archneurpsyc.1951.02320080047004.
3
The place of corticotropin in the treatment of myasthenia gravis.促肾上腺皮质激素在重症肌无力治疗中的地位。
Ann Intern Med. 1960 Apr;52:806-18. doi: 10.7326/0003-4819-52-4-806.
4
Corticosteroids in management of severe, generalized myasthenia gravis. Effectiveness and comparison with corticotropin therapy.
Neurology. 1972 Jun;22(6):603-10. doi: 10.1212/wnl.22.6.603.
5
Corticotropin therapy in myasthenia gravis: effects, indications, and limitations.重症肌无力的促肾上腺皮质激素疗法:疗效、适应证及局限性
Neurology. 1971 Oct;21(10):1008-18. doi: 10.1212/wnl.21.10.1008.
6
Short-term intensive corticotrophin treatment in myasthenia gravis.重症肌无力的短期强化促肾上腺皮质激素治疗
Proc R Soc Med. 1971 May;64(5):492. doi: 10.1177/003591577106400516.
7
Treatment of ocular myasthenia with corticotrophin.用促肾上腺皮质激素治疗眼肌型重症肌无力。
J Neurol Neurosurg Psychiatry. 1971 Feb;34(1):11-3. doi: 10.1136/jnnp.34.1.11.
8
Treatment of myasthenia gravis with adrenocorticotropic hormone (ACTH): massive short-term and maintenance treatment.促肾上腺皮质激素(ACTH)治疗重症肌无力:大剂量短期及维持治疗
J Neurol Neurosurg Psychiatry. 1969 Aug;32(4):290-6. doi: 10.1136/jnnp.32.4.290.
9
Studies in myasthenia gravis. Short-term massive corticotropin therapy.重症肌无力的研究。短期大剂量促肾上腺皮质激素治疗。
JAMA. 1966 Nov 14;198(7):699-702.
10
Results with ACTH and spironolactone in severe cases of myasthenia gravis.促肾上腺皮质激素和螺内酯治疗重症肌无力严重病例的结果。
Acta Neurol Scand Suppl. 1965;13 Pt 2:463-71. doi: 10.1111/j.1600-0404.1965.tb01915.x.