腺苷 3':5'-环磷酸依赖性蛋白激酶对核糖体相关蛋白的磷酸化作用：微粒体受体和蛋白激酶的定位
Phosphorylation of ribosome-associated protein by an adenosine 3':5'-cyclic monophosphate-dependent protein kinase: location of the microsomal receptor and protein kinase.
作者信息
Walton G M, Gill G N, Abrass I B, Garren L D
出版信息
Proc Natl Acad Sci U S A. 1971 May;68(5):880-4. doi: 10.1073/pnas.68.5.880.
Abstract
In the adrenal cortex, the adenosine 3':5'-cyclic monophosphate (cAMP)-receptor protein and the cAMP-dependent protein kinase are located in both the cytosol and endoplasmic reticulum. The cAMP-dependent protein kinase from the cytosol catalyzes the phosphorylation of ribosome-associated protein. Ribosomes washed in 0.5 M NH(4)Cl retain the substrate of the protein kinase reaction, but are dependent on the NH(4)Cl extract for in vitro protein synthesis. Dissociation of the 80S ribosomes by 0.88 M KCl, however, releases the ribosome-associated (protein) substrate of the phosphorylation reaction.
摘要
在肾上腺皮质中，腺苷3':5'-环磷酸（cAMP）受体蛋白和cAMP依赖性蛋白激酶位于细胞质和内质网中。来自细胞质的cAMP依赖性蛋白激酶催化核糖体相关蛋白的磷酸化。用0.5M NH(4)Cl洗涤的核糖体保留了蛋白激酶反应的底物，但体外蛋白质合成依赖于NH(4)Cl提取物。然而，用0.88M KCl使80S核糖体解离会释放磷酸化反应的核糖体相关（蛋白质）底物。
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