Schnitzer B, Rucknagel D L, Spencer H H, Aikawa M
Science. 1971 Jul 16;173(3993):251-2. doi: 10.1126/science.173.3993.251.
Vacuoles containing inclusions were observed by transmission electron microscopy in erythrocytes of a splenectomized patient with hemoglobin Ann Arbor. The membranes of these vacuoles became fused with the surface membrane of the red cell, thus opening the vacuoles and exposing their contents to the outside. These vacuoles when they have become thus attached to the cell membrane of the erythrocyte are responsible for the pits observed with scanning electron microscopy.
在一名患有血红蛋白安阿伯病的脾切除患者的红细胞中，通过透射电子显微镜观察到含有内含物的液泡。这些液泡的膜与红细胞的表面膜融合，从而打开液泡并将其内容物暴露于外部。这些液泡在如此附着于红细胞膜时，就是扫描电子显微镜下观察到的凹坑的成因。
