De Clercq E, De Somer P
Science. 1971 Jul 16;173(3993):260-2. doi: 10.1126/science.173.3993.260.
Separate administration of polyribocytidylic acid [poly(rC)] and polyriboinosinic acid [poly(rI)] to cell cultures in vitro resulted in an antiviral activity identical to or greater than that resulting from addition of the poly(rI) * poly(rC) complex. Priming of cells with poly(rI), followed by treatment with poly(rC), gave a consistently greater antiviral activity than poly(rI) * poly(rC) itself. This priming effect was obtained in several cell cultures challenged with different viruses. In vivo, the antiviral activity of poly(rI) * poly(rC) was only partially restored if poly(rI) and poly(rC) were injected separately; prior injection of poly(rI) proved superior in restoring this antiviral activity as compared to prior injection of poly(rC).
在体外细胞培养中分别给予聚核糖胞苷酸[聚（rC）]和聚核糖肌苷酸[聚（rI）]，所产生的抗病毒活性与添加聚（rI）·聚（rC）复合物所产生的抗病毒活性相同或更高。先用聚（rI）对细胞进行预处理，然后用聚（rC）处理，其抗病毒活性始终比聚（rI）·聚（rC）本身更高。在用不同病毒攻击的几种细胞培养物中都观察到了这种预处理效应。在体内，如果分别注射聚（rI）和聚（rC），聚（rI）·聚（rC）的抗病毒活性仅部分恢复；与预先注射聚（rC）相比，预先注射聚（rI）在恢复这种抗病毒活性方面表现更优。
