钙离子对神经肌肉易化的双重作用。
A dual effect of calcium ions on neuromuscular facilitation.
作者信息
Rahamimoff R
出版信息
J Physiol. 1968 Mar;195(2):471-80. doi: 10.1113/jphysiol.1968.sp008468.
Abstract
- The changes in neuromuscular facilitation produced by varying extracellular calcium and magnesium concentrations have been studied at the frog neuromuscular junction using intracellular recording and automatic averaging of responses.2. When [Ca] was elevated three effects were observed: a large increase in transmitter release by the first impulse; a decrease in facilitation at short intervals between impulses; and a prolongation of the time course of the facilitated release. If the release by the first impulse is kept at constant level, by raising both [Ca] and [Mg], facilitation becomes greater at all impulse intervals.3. The results have been discussed in terms of the hypothesis that the action of calcium is responsible for neuromuscular facilitation.
摘要
利用细胞内记录和反应自动平均技术，在青蛙神经肌肉接头处研究了细胞外钙和镁浓度变化所产生的神经肌肉易化作用的改变。
当[Ca]升高时，观察到三种效应：第一个冲动引起的递质释放大幅增加；冲动之间短间隔时易化作用降低；易化释放的时间进程延长。如果通过提高[Ca]和[Mg]使第一个冲动的释放保持在恒定水平，则在所有冲动间隔时易化作用都会增强。
已根据钙的作用负责神经肌肉易化作用这一假说对结果进行了讨论。
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