Hoover E A, Griesemer R A
Am J Pathol. 1971 Oct;65(1):173-88.
Intravenous inoculation of pregnant cats with feline herpesvirus produced minimal illness but resulted in abortion, intrauterine fetal death and congenital fetal infection. Placental lesions included multiple infarcts in the placental labyrinth, thrombosis of maternal vessels in the endometrium and placenta, and multifocal necrosis of the giant-cell trophoblast and endometrial epithelium in the junctional zone of the placenta associated with eosinophilic intranuclear inclusion bodies. The virus was isolated from all the placentas and uteri but from none of the fetuses aborted 6-9 days after maternal intravenous inoculation. Viral antigen was demonstrated in the uterine vessels and in the junctional zone of the placenta at this time. On postinoculation day 26, viral antigen was demonstrated in the chorioallantoic membrane on the fetal side of the placenta and in the liver of a congenitally infected fetus. Although all 4 pregnant cats inoculated intranasally with feline herpesvirus aborted, neither virus, viral antigen nor significant lesions were detected in the uteri, placentas or fetuses. Abortion after intranasal inoculation was interpreted as a nonspecific reaction secondary to the severe, debilitating upper respiratory disease that occurred.
给怀孕猫静脉接种猫疱疹病毒后，猫只出现轻微病症，但会导致流产、子宫内胎儿死亡和先天性胎儿感染。胎盘病变包括胎盘迷路多处梗死、子宫内膜和胎盘母体血管血栓形成，以及胎盘交界区巨细胞滋养层和子宫内膜上皮多灶性坏死，并伴有嗜酸性核内包涵体。病毒可从所有胎盘和子宫中分离出来，但在母体静脉接种后6 - 9天流产的胎儿中均未分离出病毒。此时在子宫血管和胎盘交界区可检测到病毒抗原。接种后第26天，在胎盘胎儿侧的绒毛尿囊膜和先天性感染胎儿的肝脏中检测到病毒抗原。尽管所有4只经鼻接种猫疱疹病毒的怀孕猫均流产，但在子宫、胎盘或胎儿中均未检测到病毒、病毒抗原或明显病变。经鼻接种后的流产被解释为继发于所发生的严重、使人虚弱的上呼吸道疾病的非特异性反应。
