Burek J D, Roos R P, Narayan O
Lab Invest. 1975 Oct;33(4):400-6.
A hamster-adapted strain of equine herpesvirus-1 (equine abortion virus) caused severe hepatic degeneration in both pregnant and nonpregnant hamsters and, in addition, regularly induced abortion in pregnant hamsters inoculated at midgestation. In nonpregnant hamsters, the only consistently affected organ was the liver despite a prolonged viremia. Newborn animals usually died 1 to 2 days after inoculation; adults died 5 to 9 days after inoculation. In pregnant hamsters, the virus had a tropism for the placenta as well as the liver. The placental infection was confined almost exclusively to one cell type in the fetal portion of the placenta: the trophoblast cells of the syncytiotrophoblast zone. Necrosis of this zone led to fetal death and abortion. Infection of the fetus did not occur.
一种适应仓鼠的马疱疹病毒1型（马流产病毒）毒株在怀孕和未怀孕的仓鼠中均引起严重的肝脏变性，此外，在妊娠中期接种的怀孕仓鼠中还经常诱发流产。在未怀孕的仓鼠中，尽管病毒血症持续时间较长，但唯一持续受影响的器官是肝脏。新生动物通常在接种后1至2天死亡；成年动物在接种后5至9天死亡。在怀孕的仓鼠中，该病毒对胎盘和肝脏具有嗜性。胎盘感染几乎完全局限于胎盘胎儿部分的一种细胞类型：合体滋养层区域的滋养层细胞。该区域的坏死导致胎儿死亡和流产。未发生胎儿感染。
