无菌大鼠肠系膜中血管平滑肌的张力和反应性
Tone and reactivity of vascular smooth muscle in germfree rat mesentery.
作者信息
Baez S, Gordon H A
出版信息
J Exp Med. 1971 Oct 1;134(4):846-56. doi: 10.1084/jem.134.4.846.
Abstract
Microcirculatory observations and measurements were made by in vivo microscopy in 35 germfree and 26 conventional rats. The rate of vasomotor activity, "vasomotion," of precapillary arterioles was found markedly decreased in the germfree animals. All precapillary vessels in the germfree rats were markedly hyporeactive to the catecholamines, epinephrine and norepinephrine, as compared to similar vessels of conventional rats. The vessels in the germfree animals were also less responsive to vasopressin but not angiotensin. A greater lumen:wall ratio of primary arterioles, but not of secondary arterioles and metarterioles, found in germfree animals is related to change in vessel lumen alone without concomitant change in wall thickness. The germfree rat is characterized by possessing a hypotonic, catecholamine-refractory mesoappendix microvasculature.
摘要
通过体内显微镜检查对35只无菌大鼠和26只普通大鼠进行了微循环观察和测量。发现无菌动物的毛细血管前小动脉的血管舒缩活动速率，即“血管运动”，明显降低。与普通大鼠的类似血管相比，无菌大鼠的所有毛细血管前血管对儿茶酚胺、肾上腺素和去甲肾上腺素的反应明显减弱。无菌动物的血管对血管加压素的反应也较弱，但对血管紧张素无反应。在无菌动物中发现的初级小动脉的管腔与壁比值更大，但二级小动脉和后微动脉则不然，这仅与血管腔的变化有关，而壁厚度没有相应变化。无菌大鼠的特征是具有低渗、对儿茶酚胺不敏感的肠系膜阑尾微血管系统。
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