脊髓灰质炎病毒的缺陷干扰颗粒。I. 分离与物理性质。
Defective interfering particles of poliovirus. I. Isolation and physical properties.
作者信息
Cole C N, Smoler D, Wimmer E, Baltimore D
出版信息
J Virol. 1971 Apr;7(4):478-85. doi: 10.1128/JVI.7.4.478-485.1971.
Abstract
A class of defective interfering (DI) poliovirus particles has been identified. The first was found as a contaminant of a viral stock; others have been isolated by serial passage at a high multiplicity of infection. The DI particles are less dense than standard virus and sediment more slowly. Their ribonucleic acid (RNA) sediments more slowly than standard RNA and has a higher electrophoretic mobility. Competition hybridization experiments with double-stranded viral RNA indicate that DI RNA is 80 to 90% of the length of standard RNA. The proteins of DI particles are indistinguishable from those of standard poliovirus.
摘要
已鉴定出一类缺陷干扰（DI）脊髓灰质炎病毒颗粒。第一种是作为病毒原液的污染物被发现的；其他的则是通过在高感染复数下连续传代分离得到的。DI颗粒的密度低于标准病毒，沉降速度也更慢。它们的核糖核酸（RNA）沉降速度比标准RNA慢，且电泳迁移率更高。用双链病毒RNA进行的竞争杂交实验表明，DI RNA的长度是标准RNA的80%至90%。DI颗粒的蛋白质与标准脊髓灰质炎病毒的蛋白质无法区分。
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