Stampfer M, Baltimore D, Huang A S
J Virol. 1971 Mar;7(3):409-11. doi: 10.1128/JVI.7.3.409-411.1971.
Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity.
通过连续克隆分离制备了不含缺陷干扰颗粒的水疱性口炎病毒毒株。用这些毒株进行高倍感染不会导致干扰或缺陷干扰颗粒的形成。通过在高倍下连续传代三次产生了缺陷干扰颗粒。