Smith J A, Francis T I, Edington G M, Williams A O
Br J Cancer. 1971 Jun;25(2):337-42. doi: 10.1038/bjc.1971.43.
Human alpha fetoprotein (AFP) has been detected by the agar double diffusion method in ascitic fluid, cerebrospinal fluid (CSF) and bile, from fetuses, neonates and patients with AFP seropositive hepatocellular carcinoma. AFP was detected in the meconium and faeces of fetuses and neonates respectively. The protein was not detected in the amniotic fluid nor the pericardial fluid. It was found in the urine in only two fetuses that had concomittant renal disease. It was not detected in breast milk of lactating females. When metastases occurred in the lung from a hepatocellular carcinoma producing AFP, the pleural effusions sometimes contained AFP. The concentrations of AFP in the serum and in the other body fluids were about the same. This indicates that other body fluids can be used for the diagnosis of hepatocellular carcinoma.
采用琼脂双向扩散法，在胎儿、新生儿以及甲胎蛋白血清阳性肝细胞癌患者的腹水、脑脊液（CSF）和胆汁中检测到了人甲胎蛋白（AFP）。分别在胎儿和新生儿的胎粪及粪便中检测到了AFP。在羊水和心包液中未检测到该蛋白。仅在两名伴有肾病的胎儿尿液中发现了AFP。在哺乳期女性的母乳中未检测到AFP。当产生AFP的肝细胞癌发生肺转移时，胸腔积液中有时会含有AFP。血清和其他体液中AFP的浓度大致相同。这表明其他体液可用于肝细胞癌的诊断。
