冷暴露期间肝脏线粒体中琥珀酸氧化的变化。
Changes in the liver mitochondrial oxidation of succinate during cold-exposure.
作者信息
Aithal H N, Ramasarma T
出版信息
Biochem J. 1971 Aug;123(5):677-82. doi: 10.1042/bj1230677d.
Abstract
- Exposure of rats to low environmental temperature resulted in increased activities of several hepatic oxidative-enzyme systems. 2. Simultaneous with increase in liver ubiquinone in cold-exposed rats, the ubiquinone-dependent succinate-neotetrazolium chloride reductase activity also increased. Such an increase could also be obtained by enriching liver with ubiquinone by feeding with an exogenous source. 3. Succinate-neotetrazolium chloride reductase activity could be increased by preincubation of mitochondria with succinate and the mechanism of this activation appears to be different from that obtained on addition of ubiquinone. 4. Succinate-neotetrazolium chloride reductase activity was found to be more labile than succinate dehydrogenase on freezing and thawing and storage, and the presence of succinate gave protection against this loss in hepatic mitochondria obtained from both normal and cold-exposed animals.
摘要
- 将大鼠暴露于低温环境会导致几种肝脏氧化酶系统的活性增加。2. 在冷暴露大鼠肝脏泛醌增加的同时，泛醌依赖性琥珀酸-氯化硝基四氮唑蓝还原酶活性也增加。通过用外源泛醌喂食使肝脏富含泛醌也可获得这种增加。3. 琥珀酸-氯化硝基四氮唑蓝还原酶活性可通过线粒体与琥珀酸预孵育而增加，这种激活机制似乎与添加泛醌时获得的机制不同。4. 发现在冷冻、解冻和储存时，琥珀酸-氯化硝基四氮唑蓝还原酶活性比琥珀酸脱氢酶更不稳定，并且琥珀酸的存在可防止正常和冷暴露动物肝脏线粒体中的这种活性损失。
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