章鱼毒素对动作电位的选择性作用。
Selective effects of an octopus toxin on action potentials.
作者信息
Dulhunty A, Gage P W
出版信息
J Physiol. 1971 Oct;218(2):433-45. doi: 10.1113/jphysiol.1971.sp009626.
Abstract
- A lethal, water soluble toxin (Maculotoxin, MTX) with a molecular weight less than 540, can be extracted from the salivary glands of an octopus (Hapalochlaena maculosa).2. MTX blocks action potentials in sartorius muscle fibres of toads without affecting the membrane potential. Delayed rectification is not inhibited by the toxin.3. At low concentrations (10(-6)-10(-5) g/ml.) MTX blocks action potentials only after a certain number have been elicited. The number of action potentials, which can be defined accurately, depends on the concentration of MTX and the concentration of sodium ions in the extracellular solution.4. The toxin has no post-synaptic effect at the neuromuscular junction and it is concluded that it blocks neuromuscular transmission by inhibiting action potentials in motor nerve terminals.
摘要
一种分子量小于540的致命水溶性毒素（斑蝥毒素，MTX）可从蓝环章鱼（Hapalochlaena maculosa）的唾液腺中提取。
MTX可阻断蟾蜍缝匠肌纤维的动作电位，而不影响膜电位。延迟整流不受该毒素抑制。
在低浓度（10⁻⁶ - 10⁻⁵ g/ml）时，MTX仅在引发一定数量的动作电位后才阻断动作电位。可以精确确定的动作电位数量取决于MTX的浓度和细胞外溶液中钠离子的浓度。
该毒素在神经肌肉接头处没有突触后效应，得出的结论是它通过抑制运动神经末梢的动作电位来阻断神经肌肉传递。
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