猴病毒40的温度敏感突变体：允许性细胞的感染
Temperature-sensitive mutants of simian virus 40: infection of permissive cells.
作者信息
Tegtmeyer P, Ozer H L
出版信息
J Virol. 1971 Oct;8(4):516-24. doi: 10.1128/JVI.8.4.516-524.1971.
Abstract
Ten temperature-sensitive mutants of simian virus 40 have been isolated and characterized in permissive cells. The mutants could be divided into three functional groups and two complementation groups. Seven mutants produced T antigen, infectious viral deoxyribonucleic acid (DNA), and structural viral antigen but predominantly the empty shell type of viral particles. Two mutants produced T antigen and infectious viral DNA, but, although viral structural protein(s) could be detected immunologically, no V antigen or viral particles were found. These two functional groups of mutants did not complement each other. A single mutant was defective in the synthesis of viral DNA, viral structural antigens, and viral particles. T antigen could be detected in infected cells by fluorescent antibody but was reduced by complement fixation assay. This mutant stimulated cell DNA synthesis at the restrictive temperature and complemented the other two functional groups of mutants.
摘要
已在允许性细胞中分离并鉴定出猿猴病毒40的十个温度敏感突变体。这些突变体可分为三个功能组和两个互补组。七个突变体产生T抗原、感染性病毒脱氧核糖核酸（DNA）和病毒结构抗原，但主要产生空壳型病毒颗粒。两个突变体产生T抗原和感染性病毒DNA，但是，尽管通过免疫学方法可检测到病毒结构蛋白，但未发现V抗原或病毒颗粒。这两个功能组的突变体彼此不互补。一个单一的突变体在病毒DNA、病毒结构抗原和病毒颗粒的合成方面存在缺陷。通过荧光抗体可在感染细胞中检测到T抗原，但通过补体结合试验其含量减少。该突变体在限制温度下刺激细胞DNA合成，并能互补其他两个功能组的突变体。
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1
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Proc Natl Acad Sci U S A. 1966 Sep;56(3):918-25. doi: 10.1073/pnas.56.3.918.
2
A plaque neutralization method for arboviruses.一种用于虫媒病毒的蚀斑中和方法。
Proc Soc Exp Biol Med. 1967 Jul;125(3):741-7. doi: 10.3181/00379727-125-32194.
3
THE NATURE AND LOCALIZATION OF THE SV 40-INDUCED COMPLEMENT-FIXING ANTIGEN.猴空泡病毒40诱导的补体结合抗原的性质与定位
Proc Natl Acad Sci U S A. 1965 Mar;53(3):684-92. doi: 10.1073/pnas.53.3.684.
4
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Anal Chem. 1965 Jun;37:854-7. doi: 10.1021/ac60226a017.
5
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Proc Soc Exp Biol Med. 1965 Jan;118:85-90.
6
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Proc Natl Acad Sci U S A. 1964 Dec;52(6):1316-8. doi: 10.1073/pnas.52.6.1316.
7
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Proc Natl Acad Sci U S A. 1964 Nov;52(5):1138-42. doi: 10.1073/pnas.52.5.1138.
8
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Proc Natl Acad Sci U S A. 1964 Nov;52(5):1131-8. doi: 10.1073/pnas.52.5.1131.
9
DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.免疫荧光法检测SV40转化细胞中的特异性抗原
J Exp Med. 1964 Aug 1;120(2):121-8. doi: 10.1084/jem.120.2.121.
10
SV-40 INDUCED PROLIFERATION OF TISSUE CULTURE CELLS OF RABBIT, MOUSE, AND PORCINE ORIGIN.猴空泡病毒40诱导的兔、小鼠和猪源组织培养细胞增殖
Proc Soc Exp Biol Med. 1963 Dec;114:721-7. doi: 10.3181/00379727-114-28780.
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