猴病毒40的遗传分析。3. 一种在猴细胞生产性感染早期受阻的温度敏感突变体的特性。
Genetic analysis of simian virus 40. 3. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells.
作者信息
Robb J A, Martin R G
出版信息
J Virol. 1972 Jun;9(6):956-68. doi: 10.1128/JVI.9.6.956-968.1972.
Abstract
A temperature-sensitive mutant of simian virus 40 (SV40), ts()101, has been characterized during productive infection in monkey kidney cells. The mutant virion can adsorb to and penetrate the cell normally at the restrictive temperature, but cannot induce the synthesis of cellular deoxyribonucleic acid (DNA) nor initiate the synthesis of SV40-specific tumor, virion, or U antigens or viral DNA. First-cycle infection with purified ts()101 DNA is normal at the restrictive temperature, but the resulting progeny virions are still temperature-sensitive. The mutant neither complements nor inhibits other temperature-sensitive SV40 mutants or wild-type virions. The affected protein in the ts(*)101 mutant may be a regulatory structural protein, possibly a core protein, that is interacting with the viral DNA.
摘要
猿猴病毒40（SV40）的温度敏感突变体ts()101，已在猴肾细胞的增殖性感染过程中得到鉴定。该突变病毒粒子在限制温度下能正常吸附并穿透细胞，但不能诱导细胞脱氧核糖核酸（DNA）的合成，也不能启动SV40特异性肿瘤、病毒粒子或U抗原或病毒DNA的合成。在限制温度下，用纯化的ts()101 DNA进行的初次循环感染是正常的，但产生的子代病毒粒子仍然是温度敏感的。该突变体既不互补也不抑制其他温度敏感的SV40突变体或野生型病毒粒子。ts(*)101突变体中受影响的蛋白质可能是一种调节性结构蛋白，可能是一种核心蛋白，它与病毒DNA相互作用。
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